Therapeutics Core

Overview of Services

The mission of Augusta University Therapeutics Core (AUTC) is to provide an affordable on-campus service platform for the discovery of novel therapeutic targets and interventions for disease treatment. Our core facility is meticulously designed to foster the translation of basic scientific discoveries into pre-clinical drug development starting from target identification, to high-throughput compound screening and biological validation.

We offer tailored services that span from assay development to FDA-drug library screening, unbiased compound screening, and high-content imaging and screening to meet the diverse drug discovery needs of researchers. Our facility can empower researchers to repurpose existing FDA-approved drugs and discover new compounds for drug development, providing increased opportunities for extramural funding and patents.

The core is equipped with state-of-the-art equipment, including a Biomek i7 automated liquid handler (Beckman), a PHERAstar microplate reader (BMG LabTech), and an ImageXpress® Micro Confocal High Content Imaging System (Molecular Devices), among other advanced tools, and has the following compound libraries: an FDA-approved drug library, a kinase inhibitor library, a GPCR ligand like compound library and a 100k unbiased compound collection.

We provides the following services: 1) consultation; 2) assay development; 3) screening of an FDA-approved drug library; 4) screening of a kinase inhibitor library (or other specialized libraries); 5) pilot unbiased compound screening (up to 10k compounds), 6) HTS (100k compounds); 7) high-content imaging and screening; 8) hit selection and validation.

Leadership

Qin Wang, Professor, Director

Location and hours of operation

Links and Resources

https://web2.augusta.edu/research/core/therapeutics-core.php

Contacts